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In another embodiment, the present invention provides a method of treating or lessening the severity of a disease comprising administering to a patient in need thereof a compound of formula I, formula I, formula I i, formula II, formula II or formula II i and a BTK inhibitor, wherein the disease is selected from inflammatory bowel disease, arthritis, systemic lupus erythematosus SLE, vasculitis, idiopathic thrombocytopenic purpura ITP, rheumatoid arthritis, psoriatic arthritis, osteoarthritis, Still s disease, juvenile arthritis, diabetes, myasthenia gravis, Hashimoto s thyroiditis, Ord s thyroiditis, Graves disease, autoimmune thyroiditis, Sjogren s syndrome, multiple sclerosis, systemic sclerosis, Lyme neuroborreliosis, Guillain Barre syndrome, acute disseminated encephalomyelitis, Addison s disease, opsoclonus myoclonus syndrome, ankylosing spondylosis, antiphospholipid antibody syndrome, aplastic anemia, autoimmune hepatitis, autoimmune gastritis, pernicious anemia, celiac disease, Goodpasture s syndrome, idiopathic thrombocytopenic purpura, optic neuritis, scleroderma, primary biliary cirrhosis, Reiter s syndrome, Takayasu s arteritis, temporal arteritis, warm autoimmune hemolytic anemia, Wegener s granulomatosis, psoriasis, alopecia universalis, Behcet s disease, chronic fatigue, dysautonomia, membranous glomerulonephropathy, endometriosis, interstitial cystitis, pemphigus vulgaris, bullous pemphigoid, neuromyotonia, scleroderma, vulvodynia, a hyperproliferative disease, rejection of transplanted organs or tissues, Acquired Immunodeficiency Syndrome AIDS, also known as HIV, type 1 diabetes, graft versus host disease, transplantation, transfusion, anaphylaxis, allergies e propecia for sale in usa Guideline American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young

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